I'm likely to make (some) use of Apple's file alises in 1.2, which are an opaque way of handling files, and which are (currently, AFAIK) implemented by first checking the path, and if the file no longer exists at that path, use the inode (there are more cumbersome strategies for files on network mounted volumes).
That's one of the biggest things I like with OS X vs Windows; the ability to move and throw away stuff I'm currently using. For example, trashing an mp3 I know i'll never listen to again but at least keep it running one time, or open a movie and then immediately throw it in the trash so I don't forget later on.
Andreas