I noticed a problem with non-antialiased "programming" fonts being rendered in a strange way in my TextMate 1.5.8 (1498). Some letters will look wrong and blend with neighbouring characters.
Example screenshot for Consolas (11pt) with highlighted problem zones, note the distorted dot on the i and the blending e and {: http://www.quicksnapper.com/ballaschk/image/consolas-11pt/
Consolas is an explicitly AA-dependent, being designed for Microsoft's "ClearType" scheme. I'm fairly certain it won't look good non- antialiased at any size or resolution.
~ Daniel