Parse r' and r''' but not r" and r""" (or vice-versa) as regexes.
Parse the "r" prefix, but not the "R" prefix, as regexes.
The last option is probably the simplest. I don't think I've ever seen the "R" prefix in use and didn't even know it was an option until I just read the spec moments ago.
I've never seen 'R' in use either, but I'm sure somebody, somewhere is doing it. I think 6,7 are going to be too confusing.