I just ran into a problem where after the recent update (version 1436), all of TM's shortcuts involving the ctrl key broke.
What is an example of a shortcut which broke?
Well, not helpfully at all bug-context-wise but much to my relief, the shortcut keys started working again.
Commands that didn't work included switching language definitions, Insert Open/Close Tag in HTML, seemed like anything that didn't use the command key except some of the emacs-like shortcuts (^a, ^e, ^k, etc.). I'm sorry I can't tell you for sure.
One thing I didn't think of trying while troubleshooting the problem but have done in the meantime was to switch languages in the international panel. I sometimes jump back and forth between italian and english in the same session, and maybe that broke things.
Thanks,
--matt